Topics and Trends in Most Cited Dialysis and Renal Disease Management Papers

Ranked by citations 18 months after publication

Class of 2026 (Papers Published in 2024)

What topics and trends defined most-cited Dialysis and Renal Disease Management research in the Class of 2026?

Cardiometabolic multimorbidity, CKM syndrome, and cellular mechanisms like tubular epithelial cells define the Class of 2026 dialysis and renal disease cohort. Type 2 diabetes and cardio-renal-metabolic multimorbidity rose sharply from the Class of 2025, while serum cystatin C receded among top-cited papers.

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Updated July 19, 2026

At a glance

Field
Dialysis and Renal Disease Management
Cohort label
Class of 2026 (2024 publications)
Papers analyzed
7,336
Papers ranked
20
Top topics in ranked papers
Renal fibrosis, Cardiovascular disease, Diabetic kidney disease, Tubular epithelial cells
Publication window
Jan 1, 2024 – Dec 31, 2024
Eligibility
Research articles; reviews excluded
Citation window
18 months post-publication
18m citation range
34–1,725
Data source
OpenAlex · Retrieved Jul 2026
License
CC BY 4.0

Rankings

20 papers ranked by 18-month citation count

#1 of 7,336
1,72518m citations

A Study to Evaluate Psychological Distress and Self-Esteem Among Patients with Hemodialysis

Yogesh Kumar C -International Journal of Innovative Science and Research Technology (IJISRT)202410.38124/ijisrt/ijisrt24mar1998

Yogesh Kumar C -Unknown, Unknown

chronic kidney diseasehemodialysispsychological distressself-esteemcross-sectional studydialysis patientssocial supportFamily supportconvenient samplingmild psychological distressmoderate psychological distresssevere psychological distresslow self-esteemdiabetes mellitushypertension
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#2 of 7,336
13018m citations

A Randomized Trial of Intravenous Amino Acids for Kidney Protection

Giovanni Landoni et al.New England Journal of Medicine202410.1056/nejmoa2403769

Giovanni LandoniIRCCS San Raffaele Scientific Institute, Italy

acute kidney injurycardiac surgerycardiopulmonary bypassIntravenous amino acid therapykidney perfusionrenal functional reserveKidney Disease: Improving Global Outcomes creatinine criteriastage 3 acute kidney injurykidney replacement therapyRinger's solution30-day mortalityPROTECTION trialmultinational double-blind trialbalanced amino acid mixture2 g per kilogram ideal body weight per day
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#4 of 7,336
9118m citations

The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-κB family activation

Yating Wang et al.Kidney International202410.1016/j.kint.2024.04.016

Wei Chen, Qinghua Liu, Haiping MaoSun Yat-sen University, China

PFKFB3renal fibrosisHistone lactylationH4K12laNF-κB signalingproximal tubular epithelial cellschronic kidney diseaseischemia-reperfusion injuryglycolytic reprogramminglactate accumulationIKKβp65RelbIκBαPTC-specific deletionPFKFB3 inhibitorurinary lactate/creatine ratio
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#5 of 7,336
8518m citations

Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US Adults

Jingkuo Li et al.Journal of the American Heart Association202410.1161/jaha.124.034996

Jingkuo Li, Lubi Lei, Lihua Zhang, Yuan-Lin GuoChinese Academy of Medical Sciences and Peking Union Medical College, China

cardio-renal-metabolic multimorbidityCKM syndromesocial risk profileNHANESsubclinical cardiovascular diseasechronic kidney diseasemetabolic disorderssocial determinants of healthemployment statusincome levelfood securityeducational attainmentinsurance typehome ownershipmarital statuscumulative social disadvantage
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#6 of 7,336
6118m citations

Finerenone and Kidney Outcomes in Patients With Heart Failure

Finnian R Mc Causland et al.Journal of the American College of Cardiology202410.1016/j.jacc.2024.10.091

Finnian R. Mc CauslandBrigham and Women's Hospital, United States

Finerenoneheart failure with mildly reduced ejection fractionheart failure with preserved ejection fractionFINEARTS-HF trialkidney function declineend-stage kidney diseasemaintenance dialysiskidney transplantationurine albumin-to-creatinine ratiomicroalbuminuriamacroalbuminuriachronic kidney diseasetype 2 diabetesnonsteroidal mineralocorticoid receptor antagonistalbuminuria reductionkidney-protective effectsleft ventricular ejection fraction
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#7 of 7,336
5218m citations

IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial

Glenn M Chertow et al.Nature Medicine202410.1038/s41591-024-03043-1

Glenn M. ChertowStanford University, United States

clazakizumabIL-6maintenance dialysishigh-sensitivity C-reactive proteincardiovascular diseasediabetesmonoclonal antibodyphase 2b dose-finding studyserum fibrinogenamyloid Asecretory phospholipase A2lipoprotein(a)serum albuminthrombocytopenianeutropeniaserious infectionsinflammatory biomarkerscardiovascular risk
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#8 of 7,336
4218m citations

Projecting the economic burden of chronic kidney disease at the patient level (Inside CKD): a microsimulation modelling study

Steven Chadban et al.EClinicalMedicine202410.1016/j.eclinm.2024.102615

Juan José García SánchezRoyal Prince Alfred Hospital, Australia

chronic kidney diseasekidney replacement therapymicrosimulation modellingInside CKDeconomic burdendirect costsCKD stages 3-5KRT modalitycardiovascular complicationsheart failuremyocardial infarctionstrokehypertensiontype 2 diabetesrenal registriesCKD progressionhealthcare resource allocationpatient-level cost datadiagnosed CKD population
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#9 of 7,336
4118m citations

Lifestyle factors and their relative contributions to longitudinal progression of cardio-renal-metabolic multimorbidity: a prospective cohort study

Ning Zhang, Xiang Liu et al.Cardiovascular Diabetology202410.1186/s12933-024-02347-3

Xiong XiaoSichuan University, China

cardio-renal-metabolic multimorbidityCRMMcardiovascular diseaseCVDtype 2 diabeteschronic kidney diseaseUK Biobankmultistate modelquantile G-computationlifestyle scoresmoking statusdiet qualitysocial connectiondisease progression transitionsmultimorbidity developmentmortality risklongitudinal cohort study
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#10 of 7,336
4118m citations

Association of systemic immune-inflammation index and systemic inflammation response index with chronic kidney disease: observational study of 40,937 adults

Peixian Huang et al.Inflammation Research202410.1007/s00011-024-01861-0

Yanpei MaiSouth China University of Technology, China

systemic immune-inflammation indexsystemic inflammation response indexchronic kidney diseaseobservational studyinflammatory biomarkerskidney function assessmentpopulation-based cohortimmune-inflammation associationCKD prevalencesystemic inflammation markers
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#11 of 7,336
4018m citations

Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney

Yanjuan Hou et al.Cellular and Molecular Life Sciences202410.1007/s00018-023-05078-y

L J WangShanxi Medical University, China

diabetic kidney diseaseproximal tubuletubular epithelial cellsmitochondrial reactive oxygen speciesmitochondrial oxidative damageSS31lipid peroxidationFatty acid oxidationSphingosine-1-phosphateAcer1S1pr1SPHK1Spns2lipid droplet formationsphingolipid homeostasiscytosolic phospholipase A2HK-2 cellsmitochondria-targeted antioxidantmitochondrial cristae structurelipid metabolism reprogramming
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#12 of 7,336
4018m citations

Association of cardiovascular-kidney-metabolic health and social connection with the risk of depression and anxiety

Xinghe Huang et al.Psychological Medicine202410.1017/s0033291724002381

Wuxiang Xie, Fanfan ZhengChinese Academy of Medical Sciences and Peking Union Medical College, China

cardio-renal-metabolic multimorbidityCKM syndromeUK Biobankdepressionanxietylonelinesssocial isolationCox proportional hazards modeladditive interactionmetabolic risk factorscardiovascular diseasechronic kidney diseasesocial connectionlongitudinal cohort studyincident depressionincident anxiety
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#13 of 7,336
4018m citations

Epidemiological shifts in chronic kidney disease: a 30-year global and regional assessment

Kaili Qin, Jianbo Qing et al.BMC Public Health202410.1186/s12889-024-21065-9

Yafeng LiShanxi Medical University, China

chronic kidney diseaseGlobal Burden of Disease Studyage-standardized incidence ratedisability-adjusted life yearshealthcare access and quality indexsociodemographic indexaverage annual percentage changepopulation attributable fractionhigh fasting plasma glucosehigh systolic blood pressureCKD mortality trendsCKD prevalence trendsregional disease burdenepidemiological trendsCKD risk factors
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#14 of 7,336
3818m citations

Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury

Jiaying Li et al.Advanced Science202410.1002/advs.202411943

Xiaodong Luan, Limeng ChenChinese Academy of Medical Science and Peking Union Medical College, China

acute kidney injurymitochondrial dysfunctionHistone lactylationALDH2lysine 52 lactylationK52laproximal tubular epithelial cellssingle-cell RNA sequencingALDH2 K52R mutationSIRT3Prohibitin 2mitophagyUbiquitination-proteasomal degradationglycolytic reprogrammingimmunoprecipitation-mass spectrometryadeno-associated virusHK-2 cells
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#15 of 7,336
3618m citations

Comparative analysis of gut microbiota in incident and prevalent peritoneal dialysis patients with peritoneal fibrosis, correlations with <scp>peritoneal equilibration test</scp> data in the peritoneal fibrosis cohort

Jiangqing Fan et al.Therapeutic Apheresis and Dialysis202410.1111/1744-9987.14226

Lingyun Wang, Lulu WangChina Pharmaceutical University, China

peritoneal fibrosisperitoneal dialysisgut microbiomeperitoneal equilibration test16S rRNA sequencingdialysate-to-plasma creatinine ratioultrafiltration volumeFirmicutesTenericutesIgnavibacteriaeLactobacillalesBacilliLachnospiraceaePhenylobacteriumCaulobacteraceaeBdellovibrioPrevotellaLEfSe analysisalpha diversitySpearman correlation analysis
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#16 of 7,336
3518m citations

Association between neutrophil-to-lymphocyte ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study

Xiaowan Li, Lanyu Wang et al.Frontiers in Endocrinology202410.3389/fendo.2023.1285509

Hongyi Zhou, Hongyang XuNanjing Medical University, China

NLRdiabetic kidney diseasetype 2 diabetesalbuminuriaurine albumin-to-creatinine ratioestimated glomerular filtration rateaggregate index of systemic inflammationAISIsystemic immune-inflammation indexSIIsystemic inflammation response indexSIRIPLRMLR
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#17 of 7,336
3518m citations

Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease: multinational, longitudinal, population based, cohort study

Ping Liu et al.BMJ202410.1136/bmj-2023-078063

Pietro RavaniUniversity of Calgary, Canada

chronic kidney disease stage G3b-G4kidney failure predictionmortality predictionsuper learner algorithmestimated glomerular filtration ratealbuminuriakidney failure risk equationcompeting risk of deathBrier scoreindex of prediction accuracyurine albumin-to-creatinine rationephrology referral thresholdKDpredictpopulation-based cohorttemporal validationgeographical validationcross-validated prediction errorrisk stratificationelectronic medical records integration
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#18 of 7,336
3418m citations

Social support, family resilience and psychological resilience among maintenance hemodialysis patients: a longitudinal study

Yuxin Wang, Yuan Qiu et al.BMC Psychiatry202410.1186/s12888-024-05526-4

Chaoqun DongWenzhou Medical University, China

maintenance hemodialysispsychological resiliencefamily resiliencesocial supportlongitudinal cohort studycross-lagged analysisrepeated measures ANOVApsychological distresspsychological well-beingtertiary hospitalsdialysis centersreciprocal predictive relationshipsmaximum likelihood methodAMOSfollow-up surveysmental health interventions
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#19 of 7,336
3418m citations

Autophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney injury via miR-195a-5p-SIRT3 axis

Yujia Yuan, Longhui Yuan et al.Nature Communications202410.1038/s41467-024-47842-z

Younan Chen, Yanrong LuSichuan University, China

macrophage autophagyATG7acute kidney injurycisplatin-induced nephrotoxicitytubular epithelial cellsmacrophage-tubular epithelial cell crosstalkAtg7Δmye micemacrophage-derived exosomesmiR-195a-5pSIRT3mitochondrial dysfunctionMitochondrial respirationtubulointerstitial inflammationexosomal microRNAmiR-195a-5p-SIRT3 axistrehaloseadoptive macrophage transfermacrophage depletion
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#20 of 7,336
3418m citations

The CONVINCE randomized trial found positive effects on quality of life for patients with chronic kidney disease treated with hemodiafiltration

Matthias Rose et al.Kidney International202410.1016/j.kint.2024.07.014

Felix FischerCharité Universitätsmedizin Berlin, Germany

CONVINCE trialhigh-dose hemodiafiltrationhigh-flux hemodialysishealth-related quality of lifeend-stage kidney diseasePatient-Reported Outcome Measurement Information System (PROMIS)Cognitive functionphysical functionsocial participationpain interferenceconvection volume 23 litersphysical health summary scoremental health summary scorejoint model adjusted for mortalityuremic toxin clearancequarterly HRQoL assessmentsomnibus testsurvival benefit30-month observation periodInternational Consortium for Health Outcomes Measurement (ICHOM)
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Dominant research themes and year-over-year shifts in Dialysis and Renal Disease Management

What Topics Define the Class of 2026?

The informative word cloud across the 50 highest 18-month-cited dialysis and renal disease management papers reveals a field centered on kidney pathophysiology, cardiometabolic comorbidity, and cellular mechanisms—not generic dialysis terminology. Renal fibrosis leads at 7 of 50 papers (normalized frequency 0.14), alongside cardiovascular disease (6 papers, 0.12) and diabetic kidney disease (6 papers, 0.12). This cluster is complemented by a strong cellular focus, with tubular epithelial cells appearing in 6 papers (0.12). Cardiometabolic overlap is further evidenced by type 2 diabetes and cardio-renal-metabolic multimorbidity (both 5 papers, 0.10), as well as NHANES epidemiology (5 papers, 0.10). Other mid-sized terms emphasize acute kidney injury (4 papers, 0.08), CKM syndrome (4 papers, 0.08), and proximal tubular epithelial cells (4 papers, 0.08). After informativeness filtering, broad labels such as chronic kidney disease and end-stage kidney disease are excluded, highlighting specific fibrotic mechanisms, cardiometabolic phenotypes, and cellular drivers over umbrella disease names.

Leading research themes
Leading research themes

How Did Topics Shift from the Class of 2025 to the Class of 2026?

Comparing normalized concept frequencies between the Class of 2025 (2023 publications) and Class of 2026 (2024 publications) cohorts shows a reorientation of early-high-impact research toward cardiometabolic multimorbidity and specific cellular mechanisms. Cardio-renal-metabolic multimorbidity and type 2 diabetes exhibited the largest gains among informative concepts (both +0.08 normalized frequency; 1 versus 5 papers), closely followed by emerging topics absent from the 2023 top cohort: CKM syndrome and proximal tubular epithelial cells (both +0.08; 0 versus 4 papers). The topic evolution card underscores that Class of 2026 bars also extend further for renal aging, UK Biobank, and systemic inflammation indices (all +0.06; 0 versus 3 papers). Core pathologies like renal fibrosis, cardiovascular disease, and diabetic kidney disease also saw modest increases (+0.04). Conversely, serum cystatin C showed a steep decline (−0.08; 7 versus 3 papers), and heart failure declined slightly (−0.02; 4 versus 3 papers). Together, these shifts suggest that the most-cited 2024 papers increasingly emphasize broad cardiometabolic intersections, inflammatory phenotyping, and tubular cellular responses.

How topics shifted year over year
How topics shifted year over year
Methodology

PRI identifies high-impact research using a transparent, topic-agnostic framework applied consistently across scientific domains. Bibliographic records are drawn from OpenAlex, including publication dates, citation relationships, and document types.

This ranking covers the Class of 2026 cohort: journal articles published in 2024. Reviews and other non-article document types are excluded to ensure comparability.

Research impact is quantified with an 18-month post-publication citation window—the number of citing works published within 18 months of each paper's publication date. This metric captures early impact while controlling for publication age.

An LLM-based relevance classifier then reviews each candidate's title and abstract to confirm substantive alignment with the target domain. Only papers classified as relevant appear in the final ranking.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459

Full methodologyGitHubbioRxiv preprint

Cite this ranking

Pepkio Research Index (PRI). Topics and Trends in Most Cited Dialysis and Renal Disease Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/dialysis-and-renal-disease-management/2026. Accessed 2026-08-20.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459