The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-κB family activation
#5PRI RANKED
Most Cited Paper
in Dialysis and Renal Disease Management
18 Months Post-Publication
Class of 2026
“The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-κB family activation”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/dialysis-and-renal-disease-management/2026/
Topics
PFKFB3 · glycolytic reprogramming · histone lactylation · H4K12la · NF-κB signaling activation · Renal fibrosis · Chronic kidney disease · ischemia-reperfusion injury · Proximal tubular epithelial cells · PTC-specific PFKFB3 deletion · PFKFB3 inhibitor · lactate metabolism · IKKβ activation · IκBα · p65 · Ikbkb · Rela · Relb · urinary lactate/creatine ratio · kidney inflammation
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Dialysis and Renal Disease Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/dialysis-and-renal-disease-management/2026. Accessed 2026-07-13. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459