Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury

🏆 Top 20📊 OpenAlex

Most Cited Paper

in Dialysis and Renal Disease Management

18 Months Post-Publication

Class of 2026

“Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury”

AuthorsJiaying Li et al.

Xiaodong Luan, Limeng Chen

JournalAdvanced Science

Chinese Academy of Medical Science and Peking Union Medical College

Citations38

DOI10.1002/advs.202411943

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Topics

acute kidney injury · mitochondrial dysfunction · Histone lactylation · ALDH2 · ALDH2 · lysine 52 lactylation · K52la · proximal tubular epithelial cells · single-cell RNA sequencing · ALDH2 K52R mutation · SIRT3 · Prohibitin 2 · Prohibitin 2 · mitophagy · Ubiquitination-proteasomal degradation · glycolytic reprogramming · immunoprecipitation-mass spectrometry · adeno-associated virus · HK-2 cells

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Dialysis and Renal Disease Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/dialysis-and-renal-disease-management/2026. Accessed 2026-08-20.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459