The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-κB family activation
#4PRI RANKED
Most Cited Paper
in Dialysis and Renal Disease Management
18 Months Post-Publication
Class of 2026
“The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-κB family activation”
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Topics
PFKFB3 · renal fibrosis · Histone lactylation · H4K12la · NF-κB signaling · proximal tubular epithelial cells · chronic kidney disease · ischemia-reperfusion injury · glycolytic reprogramming · lactate accumulation · IKKβ · p65 · Relb · IKKβ · IκBα · p65 · PTC-specific deletion · PFKFB3 inhibitor · urinary lactate/creatine ratio
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Dialysis and Renal Disease Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/dialysis-and-renal-disease-management/2026. Accessed 2026-08-20. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459