Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients

🏆 Top 10📊 OpenAlex

#3PRI RANKED

Most Cited Paper

in Vector-borne infectious diseases

18 Months Post-Publication

Class of 2026

“Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients”

AuthorsAstrid Marchal, Andrea Fortova, Michaela Berankova, Alessandro Borghesi, Anne Puel, Paul Bastard, Aurélie Velay, Martin Martinot, Yves Hansmann, Judith H Aberle, Daniel Ruzek, Aurélie Cobat, Shen-Ying Zhang, Jean-Laurent Casanova et al.

Astrid Marchal, Andrea Fortova, Michaela Berankova, Alessandro Borghesi, Anne Puel, Paul Bastard, Aurélie Velay, Martin Martinot, Yves Hansmann, Judith H Aberle, Daniel Ruzek, Aurélie Cobat, Shen-Ying Zhang, Jean-Laurent Casanova

JournalThe Journal of Experimental Medicine

Institut National de la Santé et de la Recherche Médicale (INSERM)

Citations28

DOI10.1084/jem.20240637

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Topics

tick-borne encephalitis · tick-borne encephalitis virus · autoantibodies neutralizing type I interferons · IFN-α2 · IFN-β · IFN-ω · severe encephalitis · autoantibodies neutralizing type I interferons · Asymptomatic infection · odds ratios for severe TBE · 100 pg/ml IFN-α2 neutralization · 10 ng/ml IFN-α2 neutralization · hospitalized TBE patients · European TBE cohorts · Austria cohort · Czech Republic cohort · France cohort · type I IFN immunity · tick-borne transmission · TBE disease severity stratification

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Vector-borne infectious diseases Papers, Class of 2026. https://pri.pepkio.com/top-papers/vector-borne-infectious-diseases/2026. Accessed 2026-07-31.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459