Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
#2PRI RANKED
Most Cited Paper
in T-cell and B-cell Immunology
18 Months Post-Publication
Class of 2026
“Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/
Topics
T cell exhaustion · SLC16A11 · SLC16A11 · lactate metabolism · monocarboxylate transporter · CD8+ T cells · Tumor microenvironment · T cell receptor activation · Coinhibitory receptors · Polyfunctional T cells · conditional gene deletion · antibody-mediated targeting · lactic acid uptake · Antitumor immunity · tumor-bearing mouse model · immunosuppressive metabolism · Terminally exhausted T cells · effector function restoration · tumor growth reduction
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Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459