Programming tissue-sensing T cells that deliver therapies to the brain

🏆 Top 20📊 OpenAlex

Most Cited Paper

in T-cell and B-cell Immunology

18 Months Post-Publication

Class of 2026

“Programming tissue-sensing T cells that deliver therapies to the brain”

AuthorsMilos S Simic, Payal B Watchmaker et al.

Milos Simic, Payal Watchmaker, Scott S. Zamvil, Hideho Okada, Wendell A. Lim

JournalScience

University of California San Francisco

Citations76

DOI10.1126/science.adl4237

A research intelligence initiative by Pepkio

pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/

Topics

Synthetic Notch receptors · CNS-specific antigens · CNS extracellular matrix · tissue-sensing T cells · chimeric antigen receptor · brain tumor targeting · Interleukin-10 · neuroinflammation model · conditional payload expression · glial cell surface molecules · neuronal surface molecules · primary brain tumors · secondary brain tumors · anatomically targeted therapy · immunosuppressive cytokine delivery · cross-reactivity avoidance · engineered T cell programming

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Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459