PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
Most Cited Paper
in T-cell and B-cell Immunology
18 Months Post-Publication
Class of 2026
“PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/
Topics
Prostaglandin E2 · Precursor exhausted T cells · Tumor-infiltrating lymphocytes · EP2 receptor · EP4 receptor · effector T cell differentiation · Immune evasion · interleukin-2 signalling · IL-2 responsiveness · intratumoural T cell expansion · EP2/EP4 ablation · prostaglandin E2 signalling · early effector T cells · late effector T cells · draining lymph node priming · PGE2-EP2/EP4 axis · tumour elimination · Immunotherapy resistance
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Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459