The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Most Cited Paper
in T-cell and B-cell Immunology
18 Months Post-Publication
Class of 2026
“The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/
Topics
Fc–IL-4 · type 2 cytokine · exhausted CD8+ T cells · Terminally exhausted T cells · Terminally exhausted T cells · type 1 immunity · Adoptive cell therapy · Immune checkpoint blockade · STAT6 pathway · mTOR pathway · Glycolysis · NAD concentration · lactate dehydrogenase A · LDHA-dependent mechanism · metabolic modulation · type 2 immunity · syngeneic tumour models · xenograft tumour models · cancer immunotherapy synergy
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Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459