Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD
Most Cited Paper
in RNA Research and Splicing
18 Months Post-Publication
Class of 2026
“Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/rna-research-and-splicing/2026/
Topics
TDP-43 · cryptic exons · amyotrophic lateral sclerosis · frontotemporal dementia · aberrant splicing · de novo proteins · human iPSC-derived neurons · cerebrospinal fluid · TDP-43 depletion · TDP-43 pathology · cryptic peptides · transcript variants · coordinated transcriptomic and proteomic studies · postmortem brain tissue · protein-protein interactions · ALS/FTD pathophysiology · cryptic exon translation · CSF biomarkers
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Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026. Accessed 2026-07-21. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459