Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain

Topics

single-cell long-read sequencing · RNA isoforms · brain isoform map · cell-type-specific splicing · transcription start site variation · polyadenylation site variation · neurotransmitter transport genes · synapse turnover genes · postnatal day 21-to-postnatal day 28 transition · adolescent brain development · developmental isoform regulation · regional isoform regulation · mouse brain · human hippocampus · cross-species isoform conservation · human-specific isoforms · full-length isoform expression · protein architecture variation · disease-causing variants · cell subtype isoform variability