Lactylation‐Driven IGF2BP3‐Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC
#2PRI RANKED
Most Cited Paper
in RNA modifications and cancer
18 Months Post-Publication
Class of 2026
“Lactylation‐Driven IGF2BP3‐Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/
Topics
lenvatinib resistance · hepatocellular carcinoma · lactylation · IGF2BP3 · PCK2 · NRF2 · metabolic reprogramming · m6A · S-adenosylmethionine (SAM) · glycolysis · lactate · antioxidant defense system · m6A · lactylated IGF2BP3-PCK2-SAM-m6A loop · 2-DG (glycolysis inhibitor) · siRNA targeting IGF2BP3 · liposome delivery · metabolic adaptation · epigenetic remodeling · molecular-targeted therapy resistance
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Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459