Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d
Most Cited Paper
in RNA Interference and Gene Delivery
18 Months Post-Publication
Class of 2026
“Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/
Topics
Ionizable lipids · Lipid nanoparticles · amine headgroups · TLR4 · CD1d · immune responses · Receptor-ligand interactions · innate immunity · Lipid design · Immunogenicity
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Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459