Durable and efficient gene silencing in vivo by hit-and-run epigenome editing
Most Cited Paper
in RNA Interference and Gene Delivery
18 Months Post-Publication
Class of 2026
“Durable and efficient gene silencing in vivo by hit-and-run epigenome editing”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/
Topics
hit-and-run epigenome editing · durable epigenetic silencing · Pcsk9 · zinc-finger proteins · Lipid nanoparticles · mRNA delivery · epigenetic repressive marks · liver regeneration · heritability of epigenetic state · Evolved engineered transcriptional repressor · Evolved engineered transcriptional repressor · DNA-binding platform · cholesterol homeostasis · hepatocytes · transient editor delivery · gene silencing without DNA breaks · in vivo epigenetic therapeutics
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Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459