Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses

Topics

single-nuclei multi-omics · Female reproductive aging · single-nuclei RNA-seq · single-nuclei ATAC-seq · chromatin accessibility · mTOR signaling · CEBPD transcription factor · Age at menopause · cell-type-specific regulatory networks · non-coding regulatory variants · gene regulatory networks · reproductively aged ovaries · Female reproductive aging · epigenomic changes · functional genetic variants · Ovarian cell atlas · transcriptomic aging signatures · menopause-associated variants · ovary-specific aging pathways