A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
Most Cited Paper
in Receptor Mechanisms and Signaling
18 Months Post-Publication
Class of 2026
“A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR”
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Topics
TAS2R14 · Bitter taste receptors · Bitter taste receptors · flufenamic acid · gustducin · Cryo-electron microscopy · dual binding site · transmembrane bundle · intracellular binding pocket · BRET-based ligand binding assay · GPCR promiscuity · nonsteroidal anti-inflammatory drug · receptor-G protein interface · extraoral TAS2R expression · bitter taste signaling · site-targeted compound design
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459