RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade
Most Cited Paper
in Receptor Mechanisms and Signaling
18 Months Post-Publication
Class of 2026
“RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade”
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Topics
KRAS G12C · sotorasib · adagrasib · non-small cell lung cancer · covalent inhibitors · GDP-bound inactive state · GTP-bound active state · acquired resistance mutations · KRAS-GTP loading · RMC-4998 · RMC-6291 · KRAS G12C(ON) inhibitor · KRAS G12C(OFF) inhibitor · tri-complex inhibitor · adaptive resistance mechanisms · combination therapy · patient-derived models
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459