Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement
Most Cited Paper
in Receptor Mechanisms and Signaling
18 Months Post-Publication
Class of 2026
“Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement”
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Topics
fentanyl · μ-opioid receptor · positive reinforcement · negative reinforcement · ventral tegmental area · central amygdala · GABAergic neurons · Dopaminergic neuron · nucleus accumbens · opioid withdrawal · µ-opioid receptor knockdown · dopamine transients · optogenetic stimulation · place aversion · lever pressing · neuronal ensembles · circuit adaptations · opioid dependence
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Receptor Mechanisms and Signaling Papers, Class of 2026. https://pri.pepkio.com/top-papers/receptor-mechanisms-and-signaling/2026. Accessed 2026-07-29. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459