Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation
Most Cited Paper
in Monoclonal and Polyclonal Antibodies Research
18 Months Post-Publication
Class of 2026
“Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/
Topics
antibody-targeted lipid nanoparticles · Bioconjugation chemistry · complement activation · antibody-drug conjugate · biodistribution changes · phagocyte uptake in lungs · platelet count reduction · dibenzocyclooctyne click chemistry · thiol-maleimide chemistry · antibody aggregation on nanoparticle surface · free maleimide-albumin conjugation · albumin clustering · complement cascade of plasma proteins · opsonization · nanomedicine toxicity · drug delivery systems · COVID-19 vaccine-inspired lipid nanoparticles · engineered chemistry solutions to reduce complement activation
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459