Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody–Drug Conjugates
Most Cited Paper
in Monoclonal and Polyclonal Antibodies Research
18 Months Post-Publication
Class of 2026
“Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody–Drug Conjugates”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/
Topics
antibody-drug conjugate · exolinker · valine-citrulline linker · p-aminobenzylcarbamate · Drug-to-antibody ratio · premature payload release · hydrophobicity-induced aggregation · glutamic acid hydrophilic spacer · cleavable peptide linker · carboxylesterase stability · human neutrophil elastase · Cytotoxic payload · circulatory stability · tumor payload release · exo position repositioning · in vivo ADC profile · DAR improvement · linker design
Share
Cite this ranking
Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459