Addressing the antibody germline bias and its effect on language models for improved antibody design
Most Cited Paper
in Monoclonal and Polyclonal Antibodies Research
18 Months Post-Publication
Class of 2026
“Addressing the antibody germline bias and its effect on language models for improved antibody design”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/
Topics
immunoglobulin germline genes · antibody language model · protein language model · V(D)J recombination · somatic hypermutation · somatic hypermutation · AbLang-2 · immunoglobulin germline genes · paired antibody sequences · unpaired antibody sequences · antibody variable domain · therapeutic antibody design · antibody developability · mutation suggestion for binding affinity · pre-training bias in language models · antibody language model
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459