mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies

🏆 Top 10📊 OpenAlex

Most Cited Paper

in Monoclonal and Polyclonal Antibodies Research

18 Months Post-Publication

Class of 2026

“mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies”

AuthorsZhenfei Xie, Ying-Cing Lin, Jon M Steichen, Gabriel Ozorowski et al.

Zhenfei Xie, Ying‐Cing Lin, Jon M. Steichen, Gabriel Ozorowski, Andrew B. Ward, William R. Schief, Facundo D. Batista

JournalScience

The Ragon Institute of Mass General, MIT, and Harvard

Citations50

DOI10.1126/science.adk0582

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pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026/

Topics

mRNA-LNP delivery · Germline-targeting immunogen · N332-GT5 · Broadly neutralizing antibodies · V3-glycan epitope · Humanized mouse model · memory B cells · germinal center reaction · epitope analysis · B cell receptor modification · somatic hypermutation · affinity maturation · prime-boost immunization strategy · off-target V1-binding responses · precursor B cells · HIV vaccine design · lipid nanoparticle formulation · cross-reactivity minimization · protein trimer immunogen design · Broadly neutralizing antibodies

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Monoclonal and Polyclonal Antibodies Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/monoclonal-and-polyclonal-antibodies-research/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459