Comprehensive Impurity Profiling of mRNA: Evaluating Current Technologies and Advanced Analytical Techniques
Most Cited Paper
in Molecular Biology Techniques and Applications
18 Months Post-Publication
Class of 2026
“Comprehensive Impurity Profiling of mRNA: Evaluating Current Technologies and Advanced Analytical Techniques”
A research intelligence initiative by Pepkio
pri.pepkio.com
Topics
in vitro transcription (IVT) · mRNA impurities · ion-pair reversed-phase liquid chromatography · Capillary electrophoresis · Capillary electrophoresis · poly(A) tail length heterogeneity · double-stranded mRNA (dsRNA) · dsRNA 3'-loop back form · mass photometry · native mass spectrometry · mRNA aggregates · aborted poly(A) addition · partial hydrolysis · mRNA intact mass · stability-indicating methods · high-throughput impurity profiling · mRNA therapeutics quality control · mRNA sequence heterogeneity
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Molecular Biology Techniques and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/molecular-biology-techniques-and-applications/2026. Accessed 2026-07-24. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459