Exosomal miR-106a-5p from highly metastatic colorectal cancer cells drives liver metastasis by inducing macrophage M2 polarization in the tumor microenvironment
Most Cited Paper
in MicroRNA in disease regulation
18 Months Post-Publication
Class of 2026
“Exosomal miR-106a-5p from highly metastatic colorectal cancer cells drives liver metastasis by inducing macrophage M2 polarization in the tumor microenvironment”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026/
Topics
exosomal miR-106a-5p · colorectal cancer liver metastasis · M2 macrophage polarization · Tumor microenvironment crosstalk · SOCS6 · JAK2/STAT3 pathway · hnRNPA1 · single-cell RNA sequencing · CD206 · exosome-mediated communication · miRNA pull-down · RNA immunoprecipitation · Luciferase reporter assay · plasma exosome biomarker · ultracentrifugation · nanoparticle tracking analysis · transmission electron microscopy · macrophage M2 phenotype · exosomal miRNA transport · liver metastasis model
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Pepkio Research Index (PRI). Topics and Trends in Most Cited MicroRNA in disease regulation Papers, Class of 2026. https://pri.pepkio.com/top-papers/microrna-in-disease-regulation/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459