Evolution-inspired engineering of nonribosomal peptide synthetases

🏆 Top 10📊 OpenAlex

Most Cited Paper

in Microbial Natural Products and Biosynthesis

18 Months Post-Publication

Class of 2026

“Evolution-inspired engineering of nonribosomal peptide synthetases”

AuthorsKenan A J Bozhüyük, Leonard Präve, Carsten Kegler, Leonie Schenk et al.

Kenan A. J. Bozhüyük, Leonard Präve, Carsten Kegler, Leonie Schenk, Helge B. Bode

JournalScience

Max Planck Institute for Terrestrial Microbiology

Citations56

DOI10.1126/science.adg4320

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Topics

nonribosomal peptide synthetases · NRPS engineering · phylogenetic analysis · Thiolation domain · Thiolation domain · recombination sites · eXchange Unit between T domains · eXchange Unit between T domains · natural products · megasynthetases · assembly line biosynthesis · GC content · extender unit specificity · proteasome inhibitor · NRPS fragment assembly · module exchange · evolution-inspired design

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Microbial Natural Products and Biosynthesis Papers, Class of 2026. https://pri.pepkio.com/top-papers/microbial-natural-products-and-biosynthesis/2026. Accessed 2026-10-24.

Methodology
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