Ketogenic β‐hydroxybutyrate regulates β‐hydroxybutyrylation of <scp>TCA</scp> cycle‐associated enzymes and attenuates disease‐associated pathologies in Alzheimer's mice
Most Cited Paper
in Metabolism and Genetic Disorders
18 Months Post-Publication
Class of 2026
“Ketogenic β‐hydroxybutyrate regulates β‐hydroxybutyrylation of <scp>TCA</scp> cycle‐associated enzymes and attenuates disease‐associated pathologies in Alzheimer's mice”
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Topics
Lysine β-hydroxybutyrylation · β-hydroxybutyrylation quantitative proteomics · 4D label-free proteomics · APP/PS1 mice · TCA cycle-associated enzymes · citrate synthase (CS) · succinate-CoA ligase subunit alpha (SUCLG1) · β-hydroxybutyrate · ketogenic diet · ATP production · lysine 393 site in CS · lysine 81 site in SUCLG1 · Amyloid pathology · Microglial activation · Post-translational modification · enzymatic activity regulation · energy metabolism in Alzheimer's disease · β-hydroxybutyrate brain levels · Alzheimer's disease intervention · Post-translational modification
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459