Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism
Most Cited Paper
in Metabolism and Genetic Disorders
18 Months Post-Publication
Class of 2026
“Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism”
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Topics
Hepatocyte-specific arginase 2 knockout · Hepatocyte-specific arginase 2 knockout · Urea cycle disorder · TCA cycle flux · Metabolic tracing · respirometry · Oxidative metabolism · glutamine anaplerosis · diet-induced obesity · nicotinamide adenine dinucleotide (NAD) repletion · hepatic lipid derangement · glucose homeostasis · fibroinflammatory liver disease · biomarker-based disease prediction · urea-TCA cycle crosstalk · hierarchical metabolic regulation · hepatocyte metabolism · middle adulthood metabolic decline · serum metabolite biomarkers · compensated urea cycle defect
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459