Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy
Most Cited Paper
in Metabolism and Genetic Disorders
18 Months Post-Publication
Class of 2026
“Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy”
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Topics
ketogenic diet · β-hydroxybutyrate · GABA/glutamate ratio · HDAC inhibition · H3K27 acetylation · SIRT4 upregulation · Glutamate decarboxylase 1 (GAD1) · Glutamate dehydrogenase de-carbamylation · Glutamate dehydrogenase inactivation · Pentetrazol-induced epilepsy model · Refractory epilepsy · Neuron excitation inhibition · ketone bodies · Antiepileptic metabolite · Brain GABA accumulation · Transcriptional upregulation via histone acetylation · GABA synthesis pathway · BHB administration · Anticonvulsant mechanism · Epilepsy in mice
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Metabolism and Genetic Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/metabolism-and-genetic-disorders/2026. Accessed 2026-07-24. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459