KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation

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Most Cited Paper

in Ion channel regulation and function

18 Months Post-Publication

Class of 2026

“KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation”

AuthorsXiangchan Hou et al.

Xiangchan Hou, Jiawei Ouyang, Le Tang, Pan Wu, Xiangying Deng, Qijia Yan, Lei Shi, Songqing Fan, Chunmei Fan, Can Guo, Qianjin Liao, Yong Li, Wei Xiong, Guiyuan Li, Zhaoyang Zeng, Fuyan Wang

JournalPLoS Biology

Central South University

Citations60

DOI10.1371/journal.pbio.3002666

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pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/

Topics

KCNK1 · KCNK1 · breast cancer proliferation · breast cancer metastasis · Lactate dehydrogenase A · Lactate dehydrogenase A · H3K18 lactylation · histone lysine lactylation · glycolysis · lactate production · KCNK1-LDHA binding · positive feedback loop · tumor cell stiffness · tumor cell adhesion · breast cancer biomarker · breast cancer prognosis · cancer invasion

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459