IL-10 constrains sphingolipid metabolism to limit inflammation
Most Cited Paper
in Immune Cell Function and Interaction
18 Months Post-Publication
Class of 2026
“IL-10 constrains sphingolipid metabolism to limit inflammation”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/
Topics
IL-10 signalling · very long chain ceramides · ceramide synthase 2 (CERS2) · sphingolipid metabolism · inflammatory bowel disease · innate immune cells · mono-unsaturated fatty acid synthesis · fatty acid desaturation · REL transcription factor · IL-10 deficiency · inflammatory gene expression · de novo lipogenesis · genetic deletion of Cers2 · saturated ceramide accumulation · metabolic correction of lipid homeostasis · fatty acid homeostasis in immune regulation
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-15. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459