Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion

Topics

Progenitor exhausted T cells · Terminally exhausted T cells · progenitor exhaustion-to-terminal exhaustion ratio (PETER) · tumor-associated macrophages · antigen presentation · TAM depletion · Immunotherapy response prediction · PD-1/PD-L1 blockade · glioblastoma · single-cell analysis · tumor-specific T cell subsets · cognate antigen exposure · T cell exhaustion trajectory · intratumoral cellular interactions · Progenitor exhausted T cells · anti-tumor cytotoxic function · Tumor progression · Solid tumors · TAM-T cell interactions · Immunotherapy response prediction