The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression
Most Cited Paper
in HIV Research and Treatment
18 Months Post-Publication
Class of 2026
“The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/hiv-research-and-treatment/2026/
Topics
CARD8 inflammasome · HIV protease · Simian immunodeficiency virus (SIV) · CD4+ T cell depletion · pyroptosis · quiescent cells · sooty mangabeys · natural host · Humanized mouse models · CARD8-deficient cells · virion entry · T cell activation · loss-of-function mutations · uninfected bystander cell death · non-pathogenic infection · AIDS progression
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Pepkio Research Index (PRI). Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026. Accessed 2026-07-21. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459