Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial
Topics
tirzepatide · Heart failure with preserved ejection fraction · Heart failure with preserved ejection fraction · Obesity · SUMMIT trial · glucose-dependent insulinotropic polypeptide receptor · GLP-1 receptor agonist · circulatory volume expansion · pressure overload · estimated blood volume · systolic blood pressure · C-reactive protein · Estimated glomerular filtration rate · urine albumin-creatinine ratio · NT-proBNP · troponin T · KCCQ Clinical Summary Score · 6-minute walk distance · cardiovascular-kidney end-organ damage · Inflammation
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-08-20. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459

