Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction
Most Cited Paper
in Heart Failure Treatment and Management
18 Months Post-Publication
Class of 2026
“Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026/
Topics
Heart failure with preserved ejection fraction · Diastolic dysfunction · Indole-3-propionic acid · Gut microbiota dysbiosis · Tryptophan metabolism · Metabolomics · Nicotinamide N-methyltransferase · Nicotinamide N-methyltransferase · SIRT3 · Nicotinamide · NAD+/NADH ratio · Aryl hydrocarbon receptor · NAD+ salvage pathway · oxidative stress · Inflammation · Intestinal epithelial barrier dysfunction · Metabolic alterations · Obesity · Diabetes Mellitus · Mouse model of HFpEF · Dietary supplementation · Sirt3 knockdown · Nnmt knockdown · Nnmt overexpression · Gut-heart axis · Human HFpEF cohorts · Gut bacteria-derived metabolites · Cardiac energetics · Comorbidity-driven heart failure · Therapeutic microbiome modulation
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-07-13. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459