Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2

Topics

P2Y1 receptor · P2Y1 receptor · reactive astrocytes · neuronal hyperexcitability · astrocytic Ca2+ signals · neuronal Ca2+ signals · Insulin-like growth factor binding protein 2 · Insulin-like growth factor binding protein 2 · astrocyte-specific overexpression · epilepsy model · stroke model · astrocyte-neuron interaction · excitatory signaling · genetic upregulation · astrocyte-driven neuronal excitation

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459