Designed endocytosis-inducing proteins degrade targets and amplify signals
Topics
EndoTags · endocytosis-triggering binding proteins · computational protein design · lysosomal trafficking · targeted protein degradation · insulin-like growth factor 2 receptor (IGF2R) · asialoglycoprotein receptor (ASGPR) · sortilin receptor · transferrin receptor · PD-L1 antibody · AND gate control · engineered cell secretion · LYTACs · KineTACs · genetically encoded degraders · tissue-specific degradation · endocytosis-dependent signaling amplification · antibody-drug conjugates · transmembrane protein targeting · mouse tumor model
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459

