TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation
#4PRI RANKED
Most Cited Paper
in Genomics and Chromatin Dynamics
18 Months Post-Publication
Class of 2026
“TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation”
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Topics
TRAP1 · vascular smooth muscle cell senescence · atherosclerosis · Histone H4 lysine 12 lactylation · Histone H4 lysine 12 lactylation · HDAC3 · metabolic reprogramming · aerobic glycolysis · lactate production · Senescence-associated secretory phenotype · Senescence-associated secretory phenotype · mitonuclear communication · VSMC-specific knockout · ApoeKO mice · oncogenic Ras · PROTAC-mediated degradation · histone lysine delactylase · Chromatin immunoprecipitation · senescence-associated β-galactosidase · pharmacological inhibition
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-24. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459