Machine-guided design of cell-type-targeting cis-regulatory elements

🏆 Top 10📊 OpenAlex

#3PRI RANKED

Most Cited Paper

in Genomics and Chromatin Dynamics

18 Months Post-Publication

Class of 2026

“Machine-guided design of cell-type-targeting cis-regulatory elements”

AuthorsSager J Gosai, Rodrigo I Castro et al.

Sager J. Gosai, Rodrigo Castro, Steven K. Reilly, Ryan Tewhey

JournalNature

Broad Institute of MIT and Harvard

Citations112

DOI10.1038/s41586-024-08070-z

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Topics

Cis-regulatory elements · Cell type specificity · Deep learning models · in silico optimization · massively parallel reporter assays · Regulatory sequence design · tissue-specific gene expression · motif vocabulary · off-target activity reduction · regulatory code engineering · in vivo CRE validation · therapeutic CRE applications · Regulatory sequence design · cell-type-targeting sequences · transcriptional specificity

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459