Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications
Most Cited Paper
in Genomics and Chromatin Dynamics
18 Months Post-Publication
Class of 2026
“Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications”
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Topics
epigenome editing · chromatin modifications · H3K4me3 · H3K27me3 · H2AK119ub · single-cell transcriptional readouts · promoter targeting · chromatin landscape remodeling · DNA sequence motifs · cis-regulatory context · combinatorial modifications · transcriptional silencing penetrance · modular epigenome editing platform · causal transcriptional instruction · context-dependent gene regulation · histone lysine methylation · histone ubiquitination · switch-like transcriptional effects · single-cell heterogeneity · precision perturbation
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-24. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459