Chromosomal instability as a driver of cancer progression

🏆 Top 20📊 OpenAlex

Most Cited Paper

in Genomics and Chromatin Dynamics

18 Months Post-Publication

Class of 2026

“Chromosomal instability as a driver of cancer progression”

AuthorsXuelan Chen et al.

Samuel F. Bakhoum

JournalNature Reviews Genetics

Memorial Sloan Kettering Cancer Center

Citations75

DOI10.1038/s41576-024-00761-7

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Topics

chromosomal instability · cancer progression · aneuploidy · structural chromosomal aberrations · Mitotic errors · centrosome amplification · kinetochore-microtubule attachments · spindle assembly checkpoint · DNA damage response · replication stress · chromothripsis · Micronuclei · copy number alterations · tumor heterogeneity · Metastasis · therapeutic resistance · Chromosomal missegregation · Genomic instability

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459