Cooltools: Enabling high-resolution Hi-C analysis in Python

🏆 Top 10📊 OpenAlex

#1PRI RANKED

Most Cited Paper

in Genomics and Chromatin Dynamics

18 Months Post-Publication

Class of 2026

“Cooltools: Enabling high-resolution Hi-C analysis in Python”

AuthorsOpen2C et al.

Open2C, Nezar Abdennur, Sameer Abraham, Geoffrey Fudenberg, Ilya M. Flyamer, Aleksandra A. Galitsyna, Anton Goloborodko, Maxim Imakaev, Betül Akgöl Oksuz, Sergey V. Venev

JournalPLoS Computational Biology

University of Massachusetts Chan Medical School

Citations137

DOI10.1371/journal.pcbi.1012067

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Topics

cooltools · Hi-C analysis · Chromosome conformation capture · 3C technologies · Contact frequency · 3D genome organization · cooler format · high-resolution datasets · computational analysis pipeline · Python API · command line interface · scalable analysis · genome folding datasets · open2c · high-performance computing clusters · interactive analysis environments

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459