Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers
Most Cited Paper
in DNA Repair Mechanisms
18 Months Post-Publication
Class of 2026
“Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/
Topics
WRN inhibitor · HRO761 · synthetic lethality · Microsatellite instability · Microsatellite instability · WRN helicase · allosteric inhibition · D1 helicase domain · D2 helicase domain · DNA damage induction · p53-independent mechanism · WRN degradation · microsatellite-stable cells · Patient-derived xenograft models · Microsatellite instability · immune checkpoint inhibitors · genetic screens · pharmacological validation · oral treatment · tumor growth inhibition
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Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459