Transcription–replication conflicts underlie sensitivity to PARP inhibitors
#2PRI RANKED
Most Cited Paper
in DNA Repair Mechanisms
18 Months Post-Publication
Class of 2026
“Transcription–replication conflicts underlie sensitivity to PARP inhibitors”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/
Topics
PARP inhibitor · PARP1 · Homologous recombination deficiency · Transcription-replication conflicts · PARP1 · TIMELESS · TIPIN · Replication fork protection · early S phase · synthetic lethality · DNA double-strand breaks · trapped PARPs · transcription elongation inhibition · PARP1 enzymatic activity · HR-deficient cancers · replisome progression
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Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459