Split crRNA with CRISPR-Cas12a enabling highly sensitive and multiplexed detection of RNA and DNA

Topics

crRNA · Cas12a · SCas12a system · Amplification-free detection · Nucleic acid detection · microRNA detection · mature miRNA versus pre-miRNA differentiation · Point mutation detection · miR-21 · cervical cancer plasma samples · HPV detection · RPA combination · Attomolar detection · lateral flow assay · fluorescence-based detection · Multiplexed detection · Trans-cleavage activity · long RNA detection · biomarker quantification

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Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459