Structure and repair of replication-coupled DNA breaks
Most Cited Paper
in CRISPR and Genetic Engineering
18 Months Post-Publication
Class of 2026
“Structure and repair of replication-coupled DNA breaks”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/
Topics
CRISPR-Cas9 nicking enzymes · replication fork collapse · single-strand breaks · leading-strand nicks · lagging-strand nicks · single-ended double-strand breaks · seDSBs · double-ended double-strand breaks · deDSBs · Homology-directed repair · end resection · BRCA1 · 53BP1 · RAD51 filament formation · replication fork stability · HR-deficient cancers · genomic scarring · replication-coupled DNA breaks
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Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459