Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

🏆 Top 20📊 OpenAlex

Most Cited Paper

in CRISPR and Genetic Engineering

18 Months Post-Publication

Class of 2026

“Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing”

AuthorsSmriti Pandey, Xin D Gao et al.

David R. Liu

JournalNature Biomedical Engineering

Broad Institute of MIT and Harvard

Citations101

DOI10.1038/s41551-024-01227-1

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pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/

Topics

PASSIGE · Prime editing · Programmable recombination · Phage-assisted continuous evolution · Programmable recombination · evoBxb1 · eeBxb1 · Targeted DNA insertion · Programmable recombination · safe-harbour loci · primary human fibroblasts · PASTE · Targeted DNA insertion · Targeted DNA insertion · Targeted DNA insertion · therapeutically relevant genomic sites · donor integration efficiency · mammalian genome engineering

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Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459