AlphaFold predictions of fold-switched conformations are driven by structure memorization
Most Cited Paper
in Computational Drug Discovery Methods
18 Months Post-Publication
Class of 2026
“AlphaFold predictions of fold-switched conformations are driven by structure memorization”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/computational-drug-discovery-methods/2026/
Topics
AlphaFold · fold-switching proteins · structure memorization · Protein energetics · conformational diversity · AF2 · AF3 · Confidence score · training-set structures · coevolutionary restraints · secondary structure transitions · tertiary structure transitions · Protein structure prediction · Conformational sampling · Protein energetics · Conformational sampling · Physics-based methods · model discrimination · high energy conformations · low energy conformations
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Computational Drug Discovery Methods Papers, Class of 2026. https://pri.pepkio.com/top-papers/computational-drug-discovery-methods/2026. Accessed 2026-07-22. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459