Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers
Most Cited Paper
in Cancer-related Molecular Pathways
18 Months Post-Publication
Class of 2026
“Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers”
A research intelligence initiative by Pepkio
pri.pepkio.com
Topics
YAP-TEAD protein-protein interaction · Hippo pathway · IAG933 · direct interface disruption · TEAD lipid pocket · YAP eviction from chromatin · TEAD paralogs · mesothelioma · RAS-MAPK pathway · KRAS mutation · RTK inhibitors · MAPK inhibitors · combination therapy · lung cancer · pancreatic cancer · colorectal cancer · Hippo-mediated transcription · Tumor regression · YAP oncogenic functions
Share
Cite this ranking
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-24. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459