Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

🏆 Top 10📊 OpenAlex

Most Cited Paper

in Cancer-related Molecular Pathways

18 Months Post-Publication

Class of 2026

“Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers”

AuthorsStephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler et al.

Henrik Möbitz, Marta Cortés-Cros

JournalNature

Novartis BioMedical Research

Citations69

DOI10.1038/s41586-024-07350-y

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Topics

WRN helicase · HRO761 · microsatellite instability · microsatellite instability · synthetic lethality · Allosteric inhibition · D1 and D2 helicase domains · DNA damage · p53-independent mechanism · WRN degradation · microsatellite-stable cells · patient-derived xenograft · colorectal cancer · immune checkpoint inhibitors · RecQ helicase · pharmacological WRN inhibition · genetic screens · microsatellite instability

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459