Lactate enhances NMNAT1 lactylation to sustain nuclear NAD+ salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions

🏆 Top 20📊 OpenAlex

Most Cited Paper

in Cancer-related Molecular Pathways

18 Months Post-Publication

Class of 2026

“Lactate enhances NMNAT1 lactylation to sustain nuclear NAD+ salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions”

AuthorsHuimin Huang et al.

Huimin Huang, Huajun Yu, Xiaoqun Zheng, Haishan Huang, Linhua Lan

JournalCancer Letters

Wenzhou Medical University

Citations40

DOI10.1016/j.canlet.2024.216806

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Topics

lactate · NMNAT1 · Lactylation · nuclear NAD+ salvage pathway · pancreatic adenocarcinoma cells · glucose deprivation · NAD+ metabolism · post-translational modification · metabolic adaptation · cancer cell survival · nutrient stress

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459